Coordination Chemistry of Orotic acid

Our research group have been working on transistion metal complexes and their activity in the biology field, especially antimicrobial and anticancer properties. Novel pseudohalide ligands with orotic acid and its metal salt Ni(II) have been synthesized and evaluated for their antimicrobial activities by disc diffusion method. The complexes have been characterized by IR, SEM, Raman, P-Xrd and UV-Visible spectroscopic techniques.TheDiaquabis(imidazole)orotatoNickel(II),[Ni(HOr)(H2O)2(Imd)2](1),Diazidobis(orotato)nickel(II)], [Ni(HOr)2(N3)2](2),Diisocyanatobis(orotato)nickel(II)],[Ni(HOr)2(NCO)2]andDithiocyanatobis(orotato)nickel(I I)],[Ni(HOr)2(NCS)2] have been synthesized 1 and characterized by means of elemental analysis, IR, UV–Vis studies. The Ni(II) ions in [M(C5H2N2O4)(H2O)2(C3H4N2)2] the complex has a distorted octahedral coordination geometry comprised of one deprotonated pyrimidine N atom and the adjacent carboxylate O atom of the orotate ligand, two tertiary imidazole N atoms and two aqua ligands.